在面對測謊與訊問時，人腦如何在「真實」與「欺瞞」之間切換？本演講將從認知神經科學的角度，介紹決策衝突、注意控制與情緒負荷等歷程如何影響受試者在測謊題型中的反應模式。並說明如何運用腦科學與行為指標優化題型設計，以提升偵測效能與研究效度。透過跨域整合，我們得以重新理解大腦在說真話與說謊時的運作基礎。

How does the human brain shift between truth and deception during interrogation or lie-detection tasks? This talk approaches the topic from a cognitive neuroscience perspective, explaining how decision conflict, attentional control, and emotional load shape response patterns in deception paradigms. It further highlights how neural and behavioral markers can optimize item design to enhance detection accuracy and research validity. Through interdisciplinary integration, we gain new insights into how the brain operates when telling the truth—or telling a lie.