在面对测谎与讯问时，人脑如何在「真实」与「欺瞒」之间切换？本演讲将从认知神经科学的角度，介绍决策冲突、注意控制与情绪负荷等历程如何影响受试者在测谎题型中的反应模式。并说明如何运用脑科学与行为指标优化题型设计，以提升侦测效能与研究效度。透过跨域整合，我们得以重新理解大脑在说真话与说谎时的运作基础。

How does the human brain shift between truth and deception during interrogation or lie-detection tasks? This talk approaches the topic from a cognitive neuroscience perspective, explaining how decision conflict, attentional control, and emotional load shape response patterns in deception paradigms. It further highlights how neural and behavioral markers can optimize item design to enhance detection accuracy and research validity. Through interdisciplinary integration, we gain new insights into how the brain operates when telling the truth—or telling a lie.